To assess the neurophysiological effects of the HPV vaccine, forty eight female mice were either immunized with Gardasil or given phosphate-buffered saline (PBS) as a control (Fig. 1-a). Pertussis toxin (Ptx) was administrated subsequent to the vaccination to facilitate the access of the vaccine to the CNS via modulation of the blood-brain barrier (BBB)16.To assess the neurophysiological effects of the HPV vaccine, forty eight female mice were either immunized with Gardasil or given phosphate-buffered saline (PBS) as a control (Fig. 1-a). Pertussis toxin (Ptx) was administrated subsequent to the vaccination to facilitate the access of the vaccine to the CNS via modulation of the blood-brain barrier (BBB)16. As a control for autoimmune encephalomyelitis, myelin oligodendrocyte glycoprotein (MOG)35-55 was used17.