In this study, we demonstrated that the combined administration of Gardasil and Ptx induced of poor tail movement and low locomotive mobility. In addition, vaccination did not have effect on the muscular strength. Neuropathological observation reveals the following results; (1) structural damage to PVN, DMH, (2) the third ventricular atresia, (3) an increase in apoptosis around cavities of the thalamus and the hypothalamus; vascular endothelial cells in the hypothalamus were especially affected, and (4) increasing TH synthesis and decreasing GABA synthesis in the arcuate nuclei.