To Dr. Heidi Larson. First of all, the scientific evidence is that the HPV vaccines in current use have not been shown to have yet prevented a single case of cervical cancer or cancer death in spite of the prevailing optimistic assumptions. Both of the HPV vaccines are reported to be unable to induce the protective HPV specific secretory IgA antibodies on the epithelial surfaces, and to develop therapeutic cytotoxic T-cells specific to HPV-infected basal cells of the epithelium. Additionally, HPV vaccines are apparently responsible for inducing severe adverse reactions including memory disturbances and cognitive impairment which have been depriving the affected young women of their youthful days. According to the reports from the Danish Health and Medicines Authority (Denmark) and Medicines & Healthcare products Regulatory Agency (UK), the frequencies of HPV vaccine-related severe adverse events, whose complex cluster of symptoms and signs are quite similar or the same with those in our patients in Japan, were 2.7 to 3.1 among 1,000 vaccinated young women. The severity and relatively high frequency of these adverse reactions have compelled us to suspend the HPV vaccination program in the world and to establish the salvation scheme from this disastrous disease state as soon as possible. WHO and HPV vaccine companies, GSK and MSD, are primarily responsible for the investment of this salvation scheme. The clinical science asks us as clinicians to be quite sensitive and careful to see patients; especially when they show unprecedented symptoms and signs or in even more severe cases, complex cluster of symptoms and signs. The recent report from the European Medicines Agency failed to show that HPV vaccines cause CRPS and POTS. It is inevitable because the adverse reactions of HPV vaccines were not merely CRPS, POTS or juvenile fibromyalgia but rather appeared to be a complex cluster of symptoms and signs, a new syndrome. The clinical judgement is superior to the epidemiological studies in this new field, and the epidemiologists should know beforehand what must be investigated.