RESULTS: Specimens that were positive for p16(INK4A) expression were 5.3 and 16.6 times more likely to be diagnosed as CIN 2 and CIN 3 lesions, respectively, compared to CIN 1 lesions. CIN ≥ 2 lesions that were negative for the bivalent and 9-valent HR-HPV genotypes had similar rates of positive p16(INK4A) expression compared with lesions that were positive for those HR-HPV genotypes.