HPV vaccine should be administered at the target age of 11-12 years in both females and males. ACIP also recommends vaccination for females through age 26 years and for males through age 21 years who were not adequately vaccinated previouslyOn December 16, 2016 the MMWR article, "Use of a 2-Dose Schedule for Human Papillomavirus Vaccination- Updated Recommendations of the Advisory Committee on Immunization Practices" was published, detailing updated HPV vaccination recommendations. The new recommendation is for use of a 2-dose schedule for girls and boys who initiate the vaccination series at ages 9 through 14 years. Three doses remain recommended for persons who initiate the vaccination series at ages 15 through 26 years and for immunocompromised persons.Human Papillomavirus (HPV) VaccinesThe U.S. Food and Drug Administration (FDA) has approved three vaccines shown to be effective at preventing HPV infection.The bivalent HPV vaccine has FDA approval for administration to females aged 9–25 years for the prevention of cervical cancer, cervical intraepithelial neoplasia (CIN) 2 or worse and adenocarcinoma in situ, and CIN 1 caused by oncogenic HPV genotypes 16 and 18.The quadrivalent HPV vaccine is indicated to prevent cancers and intraepithelial neoplasias of the cervix, anus, vulva, and vagina and genital warts associated with HPV genotypes 6, 11, 16, and 18. The FDA has approved administration of the quadrivalent three-dose vaccine to females and males aged 9–26 years.The 9-valent HPV vaccine, approved by the FDA on December 10, 2014 for the prevention of cervical, vulvar, vaginal and anal cancers caused by HPV types 16, 18, 31, 33, 45, 52 and 58, and for the prevention of genital warts caused by HPV types 6 or 11