Any HPV type prevalence was similar in the prevaccine era (54.4%) and the vaccine era (58.1%) (Table 4). Compared with the prevaccine era, 4vHPV type prevalence was significantly lower overall in the vaccine era (18.6% vs 10.8%; aPR: 0.53 [95% CI: 0.40–0.71]) and among those vaccinated (18.6% vs 2.1%; aPR: 0.09 [95% CI: 0.05–0.18]). The 4vHPV type prevalence among those unvaccinated in the vaccine era was not significantly different from the prevaccine era (18.6% vs 16.9%). Overall or according to vaccination history, there were no statistically significant differences in the vaccine era compared with the prevaccine era in the prevalence of non-4vHPV high-risk types; HPV-31, -33, -45; or the 5 additional 9vHPV types.